"North Korea disrespected the wishes of China & its highly respected President when it launched, though unsuccessfully, a missile today".
There are 10 such existing centres in the Central Intelligence Agency, and the new addition will be the most focused in terms of geographical area and remit - the Korean Peninsula now falls under the jurisdiction of the Mission Centre for East Asia and Pacific.
But with no test forthcoming, Trump softened his hostility, even saying last week that he would be "honoured" to meet North Korean leader Kim Jong-un "under the right circumstances", raising eyebrows among foreign policy observers.
The North's state media have been running stories about the plot since last week.
"The new Mission Center will work closely with the Intelligence Community and the entire US national security community", the CIA said.
"According to our law, the Central Public Prosecutor's Office of the DPRK will use all available methods to start to work to demand the handover of the criminals involved, so as to punish the organizers, conspirators and followers of this bad state-sponsored terrorism", Han said in the extradition statement.
"US citizens in the DPRK are at serious risk of arrest and long-term detention under North Korea's system of law enforcement", the department said. Ltd., met Kim in Dandong, on North Korea's border with China, to give him communications equipment and cash.
She also said she would continue promoting non-governmental and unofficial contacts with North Korea - or "track II diplomacy" - through the Northeast Asia Cooperation Dialogue.
Reading from a prepared statement, Mr Han said: "These terrorists plotted and planned in detail for the use of biochemical substances including radioactive and poisonous substances as the means of assassination".
Last week, North Korea's Ministry of State Security claimed that a CIA-supported terrorist cell managed to infiltrate the secretive state with the goal to assassinate their supreme leader through the use of "biochemical substances".
This is the first CIA Mission Center established under President Trump, and the agency's 11th overall.
The South Korean intelligence service said the charge was "groundless".
In mid-April, expectations of a sixth North Korean nuclear test coupled with reports that a U.S. Navy carrier strike group was sailing towards the Korean Peninsula sparked fears of a renewed conflict with Pyongyang.