"I have a message for the Prime Minister, who I'm sure is watching tonight", she said.
Political leaders locked horns on topics such as the NHS and foreign aid as they went head to head in the debate.
Neither Theresa May nor Jeremy Corbyn, both of whom are just other Natalies in Nuttall's eyes, took part in the debate which lacked any real entertainment value before Nuttall got on the mic.
While Green Party leader Caroline Lucas said she does not want tougher border controls and wants to keep free movement with the EU.
He added: "Brexit would never have happened if it wasn't for Ukip!".
ITV's live general election leaders debate last night was missing the two main party chiefs after Theresa May and Jeremy Corbyn declined to take part.
Both Farron and Lucas said their parties would fight for a referendum on the final Brexit deal, though Nuttall took his counterattack to Farron, whom he accused of not respecting the referendum result.
Ukip's leader has been left red-faced after twice getting the name of his debate opponent wrong.
The Ukip leader was facing four other party leaders on Thursday and confused Wood, the Plaid Cymru leader, with. someone called Natalie.
"You may be too scared to come here tonight, for your U-turns to be highlighted, for your cruel policies to be exposed", the Welsh politician said.
Ms Wood used her opening speech to launch an attack on Mrs May for her absence.
Wood also mocked the Conservative manifesto, and said it was a "weak and unstable leadership" not to appear, in jest at the Tory PM's unofficial mantra of "strong and stable leadership".
Ms Sturgeon said people should unite against the pursuit of a "hard, extreme Brexit" which she claimed would hit more than 80,000 jobs in Scotland.
"Do you not think the British people deserve to see me and you debate live and on television?"
And the UKIP leader made the same gaffe again, saying "I think that Natalie's absolutely right, what we need to do is". "I trust the people".
"The SNP will always stand up against Tory cuts because they are damaging our public services and pushing more people into poverty".