With an eye on the big prize next Wednesday when the Red Devils take on Ajax in the Europa League final, Mourinho has chose to give his first-team squad some much needed rest on the final day of the Premier League season.
Three days before the Europa League final against Ajax, Jose Mourinho made nine changes on his 250th game as a manager in England's top flight, with Demetri Mitchell, Harrop and substitute Angel Gomes given United debuts. David Moyes succeeded Ferguson but was sacked after 34 league games and his successor, Louis van Gaal, was removed after two seasons, though he did win last year's FA Cup.
Mourinho won the UEFA Cup, as the Europa League was previously known, with Porto in 2003, but the two-time Champions League victor has been publicly dismissive of the competition in recent years.
A ideal precursor, you sense, for one last - and deciding - game on Wednesday.
Having signed the Bundesliga player of the year (Henrikh Mkhitaryan), the most expensive footballer on the planet (Paul Pogba), the outstanding Eric Bailly and the celestial Zlatan Ibrahimovic, book makers had Manchester United just behind Manchester City as favourites to win the Premier League at the start of the season.
Given the millions in prize money up for grabs that was little surprise, yet the way the hosts' callow side bossed much of the game did. I am not enjoying that."So finally they sing, they [swing] the scarves - it's nice for them".
O'Hara, born in Manchester with Irish grandparents, joined United aged eight and progressed through the ranks before gaining experience on a number of loan deals in recent years. I think he's got a terrific balance going into Wednesday.
Herrera also explained how a meeting with Mourinho saw him switch his role in the team this season - although he admits he still wants to score more goals for the club in the future.
"It was how I developed into the person and player I am now".
"I have seen in the football media that certain pundits can not understand why our players are exhausted", he wrote ahead of the game at Old Trafford.
There was no chance to ask Mourinho about his compatriot's display as the United boss zoomed out of the post-match press conference, but recently he said Pereira would be "the best Portuguese goalkeeper of the next generation".